A new intervention for depression prevention encourages positive relationships between African American mothers and daughters who are living in urban poverty. CHAS Fellow Alida Bouris and colleagues tested the “Mother-Daughter Project” through focus groups and an open trial to see whether the intervention was feasible, satisfactory, and usable for the target demographic. Results showed that while participants generally found the treatment satisfactory, the model was not necessarily feasible. The Mother-Daughter Project had significantly lower attendance rate than is seen in other internalizing prevention interventions that have been tested with African American preadolescents. Several barriers were identified as affecting the intervention’s feasibility including a lack of access to safe transportation.